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RNA Therapeutics: The "RNAissance"



  May 16, 2024

RNA Therapeutics: The "RNAissance"


 
What are RNA therapeutics?

RNA therapeutics are a novel class of medicines that utilize RNA molecules to regulate, repair, replace, or enhance gene expression. These therapies hold immense promise for treating a wide range of diseases at the genetic level.

How do RNA therapeutics work?

RNA-based drugs use various RNA molecules, including messenger RNA (mRNA), small interfering RNA (siRNA), and antisense oligonucleotides (ASOs), to influence gene expression. For instance, mRNA vaccines instruct cells to produce specific proteins, triggering immune responses.

Recent advancements:

- Improved stability and delivery of RNA molecules.

- Development of targeted delivery systems.

- Application of genetic engineering techniques.

- Success of mRNA vaccines for COVID-19 and ongoing research for other diseases.

Challenges:

- Efficient delivery to specific cells.

- Scaling up production.

- Ensuring safety and efficacy.

Future potential:

- Revolutionizing medicine.

- Personalized treatments based on individual genetics.

- Rapid response to emerging health threats.

Approved RNA therapeutics:

- mRNA vaccines for COVID-19.

- Therapies for spinal muscular atrophy and hereditary transthyretin-mediated amyloidosis.

Significance of the "RNAissance":

The "RNAissance" represents a surge in interest and investment in RNA therapeutics. It marks the transition from research to real-world healthcare solutions, driven by scientific breakthroughs and successful applications.


Keep an eye on this dynamic field—it's shaping the future of medicine! 



SRIRAM’s



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