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India’s Milestone: Completing the ‘10,000 Genome’ Project



  Feb 28, 2024

India’s Milestone: Completing the ‘10,000 Genome’ Project




India’s Department of Biotechnology (DBT) has achieved a significant milestone in genetic research by completing the ‘10,000 genome’ project. This initiative marks a pivotal advancement in understanding the genetic diversity of India’s vast population and its implications for healthcare and medicine.

Key Aspects of the ‘10,000 Genome’ Project

Objective: The project aimed to sequence 10,000 whole genomes to create a reference database reflective of India’s diverse population. This database is expected to uncover genetic variants unique to Indian population groups, facilitating the development of personalized medicine and therapies.

Collaboration: Spearheaded by the Indian Institute of Science (IISc), Bengaluru, and the Centre for Cellular and Molecular Biology (CCMB), Hyderabad, the project saw participation from about 20 institutions across India, demonstrating a collaborative effort in scientific research.

Genetic Diversity: India’s population, with over 4,600 distinct groups, many of which practice endogamy, presents a unique opportunity to study genetic variations and disease-causing mutations. This genetic diversity is a rich resource for understanding health and disease in a context specific to India.

Implications: The project has far-reaching implications for healthcare, including improved diagnostic methods, better medical counselling, development of custom drugs, advancements in gene therapy, and insights into susceptibility to infectious diseases.

Future Endeavors: While the completion of the ‘10,000 genome’ project is a monumental achievement, researchers acknowledge the need to sequence many more genomes to identify rarer mutations. This ongoing effort is crucial for the continuous improvement of healthcare outcomes.

Transparency and Collaboration: The establishment of a biobank at the Centre for Brain Research, IISc, and data archiving at the Indian Biological Data Centre (IBDC) highlights the project’s commitment to transparency and the potential for future research collaborations.

Conclusion

The ‘10,000 genome’ project is a testament to India’s commitment to leveraging genomic research for the betterment of healthcare and personalized medicine. By mapping the genetic diversity of its population, India sets a foundation for groundbreaking advancements in medical science, paving the way for more customized and effective healthcare solutions. This initiative not only places India on the global map of genomic research but also promises a future where medical treatments can be tailored to the genetic makeup of individuals, leading to more precise and effective healthcare interventions.

SRIRAM’s


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